Alzheimer Disease for Clinical and Basic Science - myassignmenthelp

Question: Discuss about theAlzheimer Disease for Clinical and Basic Science. Answer: Paragraph 1: Explanation of positive lesions and negative lesions of Alzheimers The neuropathological hallmark changes of in the brain of a person presenting with Alzheimers disease include both positive and negative lesions. Explain why some of the lesions are regarded as positive whereas others are regarded as negative. Also, differentiate between the macroscopic and microscopic features which characterise the condition. Paragraph 2: Research on the positive lesions Discuss the classical positive lesions of Alzheimers disease. These include neurofibrillary tangles, amyloid plaques, dystrophic neurites containing hyperphosphorylated tau, and neuropil threads (Serrano-Pozo, Frosch, Masliah, Hyman, 2011). Discuss the composition and the morphological characteristics of these features. Base this research on the papers by Serrano-Pozo, Frosch, Masliah, Hyman, (2011), and Perl, (2010) as they offer an in-depth research into these lesions. Paragraph 3: Research on the negative lesions These are the classical negative lesions present in patients presenting with the disease. According to Serrano-Pozo, Frosch, Masliah, Hyman, (2011), the core negative features of Alzheimer's disease include losses of neurons, neuropil, and synaptic elements. Explain the composition and morphological characteristics and relate them to the positive lesions. On top of the two research papers used in the discussion of the positive lesions, an additional research paper by Pithadia, (2008) will offer more information. Paragraph 4: Research on a patient's history as one of the clinical features resulting from pathological changes caused by Alzheimer's. Patients with this condition do exhibit progressive memory loss, spreading to other spheres of cognition which are impaired through the progression of the disease over years. An investigation of a patients history uncovers typical presentations such as memory loss accompanied with language disorders and impairment in both executive functions and in ones visuospatial skills (Lakhan, 2017). Paragraph 5: Research on the typical results of neurologic and mental status examinations during a patients initial diagnosis. Alongside a change in a patient's history, other clinical feature resulting from pathological changes brought about by the disease can be identified through a patient's physical examination. Discuss the typical results of the neurologic examination and a mental status examination when evaluating the stages of the disease and also in ruling out comorbid conditions (Korolev, (2014): Lakhan, (2017). References Korolev, I. O. (2014). Alzheimers Disease: A Clinical and Basic Science Review. Medical Student Research Journal, 24-33. Lakhan, S. E. (2017, July 25). Alzheimer Disease Clinical Presentation. Retrieved from MedScape: https://emedicine.medscape.com/article/1134817-clinical Perl, D. P. (2010). Neuropathology of Alzheimer's Disease. Mt Sinai J Med., 32-42. Pithadia, A. (2008). Pathophysiology and pharmacotherapy of Alzheimer's disease (AD). Internet Journal of Pharmacology. Serrano-Pozo, A., Frosch, M. P., Masliah, E., Hyman, B. T. (2011). Neuropathological Alterations in Alzheimer Disease. Cold Spring Harb Perspect Med., a006189.